Five-domain challenge suite

Expanded bullets

• Reaction mechanisms — budgeted pathway discovery with atom identity, graph-edit grammar, metered profiles.
• Entropic effects — microstate ensembles, thermodynamic gauge, joint enthalpy/entropy uncertainty.
• Retrosynthesis — route portfolios, hyperedges, precursor accounting, typed conditions.
• Kinetics — network discovery/control, assay budgets, robust operating policies.
• Thermochemistry — Hess-cycle evidence allocation + correlated-network successor with GLS/VoI.
• Each challenge: public instances, baseline, non-optimal reference solver, held-out synthetic families.